General Information

 

A broad spectrum of Neuroscience research opportunities is available at Iowa State University, ranging from the molecular to the behavioral level of analysis.  The program offers the Master of Science and Doctor of Philosophy degrees in the neuroscience major.  As a major area of research and study at Iowa State University, neuroscience involves faculty from the departments and programs of Animal Science; Biochemistry, Biophysics, and Molecular Biology; Biomedical Sciences; Chemical Engineering; Chemistry; Computer Science; Entomology; Health and Human Performance; Microbiology; Psychology; and Zoology and Genetics.  Currently, faculty and students are pursuing research in developmental neurobiology; effects of toxic materials and environmental factors on development; plasticity and nerve regeneration; neuroimmunology, mechanisms of signal transduction in neurons and other cells; neurendocrinology of stress and of reproduction; neuroregulatory mechanisms operating at the cell membrane level; aging and neuropathology; mathematical modeling; and Cognitive Neuroscience.

 

Admissions Requirements

 

Applicants are expected to have an undergraduate or advanced degree in one of the basic or applied sciences, such as biochemistry, biology, human medicine, immunobiology, neuroscience, physiology, pharmacology, psychology, veterinary medicine, or zoology.  Appropriate undergraduate coursework includes mathematics, chemistry, physics, and biological science.

 

Application Procedures

 

The Iowa State University’s Neuroscience Program application procedure requires a self-managed application.  At the end of this packet is a checklist for the self-managed application.  Admission to Neuroscience Program and ISU is a two-step process in which an application is required for each step. Admission to both the Neuroscience Program and ISU is required.  A self-managed application includes, the original and two photocopies of the Application for Graduate Admissions; Nonrefundable application fee of $30.00; two official academic transcripts from each previous institution attended in sealed envelopes; official GRE score; official TOEFL score for nonnative English speakers; Neuroscience Program Application; Statement of Purpose, Goals, and Research Interests; Resume or Curriculum Vitae.  A Complete application can be sent to the following address: 

Neuroscience Program

2018 Molecular Biology Building

Iowa State University

Ames, IA

50011-3260

An online application can also be found at Iowa State University Neuroscience Program’s website:  http://www.neuroscience.iastate.edu/

 

Financial Support

 

Graduate Assistantships

Financial support is available in the form of research assistantships sponsored by the neuroscience program and research grants and teaching assistantships sponsored by departments affiliated with the program.  In addition, students interested in signal transduction may be eligible for research assistantships and postdoctoral fellowships sponsored by a National Science Foundation extramural training grant.  Recipients of assistantships are assessed tuition fees at the resident rate.  Scholarship credit covering one-half of the in-state tuition is given to all students on a 20-hour assistantship.

 

PACE Awards

The Graduate College sponsors the Premium for Academic Excellence (PACE) Award program for new graduate students with outstanding academic records.  This award is equivalent to half of the resident tuition fees and may extend over one- or two-year period.  The Admissions Committee of the program nominated candidates. The student need not be on a graduate assistantship to be nominated for a PACE Award. 

 

Information about other types of financial assistance available to graduate students can be obtained from the Iowa State University’s Financial Aid website.

http://www.public.iastate.edu/~fin_aid_info/

 

Neuroscience Curriculum

 

The program emphasizes interdisciplinary education with specialization appropriate to the student’s interests.  The master’s degree requires 30 credit hours and the doctoral degree requires 72 credit hours.  The Graduate College also requires preliminary examinations at the Ph.D. level.  The master’s degree may be obtained, but is not required for the doctoral degree.  Research is an integral part of the curriculum in neuroscience at Iowa State University.  A student will select a major professor from the faculty participating in the program. The role of the major professor is to act as a mentor and guide the student’s professional development.   It is suggested that the student do at least three rotations in different labs before selecting a major professor unless they are directly admitted into a lab. 

 

Required Courses

Students not meeting specified prerequisites may seek permission from the instructor to enroll.

 

NEURO 556.  Neurobiology.           3-4 Credits.  Prerequisites: Zool 355 of Psych 310; or equivalent background, physics recommended.  Integration, coding, plasticity, and development in nervous systems.

 

 

 

 

NEURO 557.  Advanced Neuroscience Techniques.  2 Credits.  Prerequisites: NEURO 556.  Research methods and techniques; exercises and/or demonstrations representing individual faculty specialties. 

 

NEURO 660.  Current Topics in Neurobiology and Behavior. 

2-3 Credits.  May be taken more than once.  Prerequisites: permission of instructor.  Topics may include communication, hormones and behavior, neural integration, developmental neurobiology, neuroanatomy and ultrastructure, sensory biology, social behavior, techniques in neurobiology and behavior.

 

NEURO 690.  Journal Club in Neuroscience.  1 Credit.  Prerequisites: NEURO 556.  Students are required to attend and make at least one presentation at a weekly journal club focusing on current topics.

 

NEURO 696.  Neuroscience Seminar.  1 Credit.  Students are required to be enrolled in this course each semester while in the Neuroscience Program.  Prerequisites: NEURO 556.  Presentations and discussion of research by students, faculty and visiting scholars.

 

NEURO 699.  Research.

Credits vary.

 

BBMB 404.  Biochemistry. 

3 Credits.  Prerequisites: Chemistry of amino acids, proteins, carbohydrates, lipids, vitamins, and nucleotides: enzymology; metabolism of carbohydrates and lipids.

 

STAT 401.  Statistical Methods for Research Workers. 4 Credits.  Prerequisites: STAT 101. 104, 201, or 227.  Methods of analyzing and interpreting experimental and survey data.

 

Six Credits From The Following Additional Courses:

 

ComS 474.  Elements of Neural Computation.  3 Credits.  Prerequisites:  Math 165 & ComS 228 or permission of instructor.  Mathematical and computational models of neurons and networks of neurons.  Applications to Artificial Intelligence and cognitive and Neural Modeling.

 

E E 545.  Artificial Neural Networks.  3 Credits.  Prerequisites: 524.  Introduction to the fundamentals of artificial neural networks (ANNs).  Theory as well as practical implementation of networks.  Topics include uses of ANNs to biological neurons, activation functions, and architectures, supervised and unsupervised learning.  Networks investigated typically include single and mutilayer perceptrons, backpropagaton, learning algorithm, stochastic-based learning, genetic algorithms, radial basis networks, Hopfield and Hamming networks and other associative networks,  Kohonen’s networks, morphological neural networks.

 

 

PSYCH 517.  Psychopharmacology.  3 Credits.  Prerequisites: PSYCH 315, or permission of instructor.  Fundamentals of drug-behavior interactions with emphasis on psychoactive drugs and their use in experimental, therapeutic, and social settings.

 

PSYCH 519.  Cognitive Neuropsychology.  3 Credits.  Prerequisites: Permission of instructor.  Psychological models and related neurological substrates underlying cognition in normal and brain-damaged patients.  Topics include spatial perception, object and face recognition, voluntary motor control, language processing, memory, and problem solving.

 

BMS 537.  Neurobiology. 

3 Credits.  Prerequisites: 10 credits in biological sciences and permission of instructor.  Neurobiology of domestic animals.

 

BMS 511.  Functional Neuroanatomy and Morphology of Neurotransmitter Pathways.  4 Credits.  Prerequisites: 10 credits in biological sciences, permission of instructor.  Basic organizational schemes of the mammalian brain including cytoarchitecture, chemoarchitecture, and connectivity of different regions of the nervous system.

 

BMS 549.  Advanced Vertebrate Physiology.  4 Credits.  Prerequisites: Zool 355; credit or enrollment in BBMB 404 or 420.  Neurophysiology, sensory systems, muscle, neurendocrinology, and endocrinology.

 

BMS 565. Physiology and Pharmacology of Autonomic Nervous System.  2 Credits.  Alternate Springs.  Prerequisites:  BMS 549, 552 or permission of instructor.  Release of neurotransmitters and their regulation; control and regulation of autonomic functions; mechanisms of action of adrenergic and cholinergic receptors.

 

TOX 555.  Neurobehavioral Toxicology.  3 Credits.  Alternate Falls.  Prerequisites VDPAM 501.  Advanced study of neurotoxicology and behavior.  Emphasis on methods in neurobehavioral toxicology and the effects of a broad spectrum of neurotoxic agents.

 

Zool 540.  Signal Transduction. 

3 Credits.  Prerequisites: Zool 528, BBMB 404.  Mechanisms and components of cellular signal transduction including receptors, G-proteins, second messengers, protein phosphorylation, other post-translational protein modifications, and transcriptional regulation.

 

Plus 48 Credits of Research and Electives.  

 

 

 

 

 

 

Research Facilities

 

A wide variety of university-based support facilities and services supplement individual investigator’s research laboratories.  These state-of-the-art biotechnology centers include:

 

§         An image analysis facility

§         A scanning electron microscope and elemental analysis facilities

§         A nucleic acid facility for automated nucleic acid synthesis and sequencing

§         A hybridoma service for monoclonal antibody production and application

§         A protein facility for amino acid analysis, peptide synthesis, and sequencing

§         A cell facility for flow cyometry and cell sorting

§         Carver Center for Ultrahigh Resolution Microscopy

 

Iowa State University also has an outstanding statistical laboratory, computation center, and a major research library. 

 

Career Opportunities

 

Many graduates of the Neuroscience Program at Iowa State University have received jobs in biological sciences departments of universities, medical colleges, pharmaceutical companies and government laboratories.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Neuroscience Faculty

 

Neuroscience Faculty is listed according to their home departments.

 


Animal Science

 

Lloyd Anderson

Mechanisms regulating relaxin and progesterone secretion and their effects; effects of antiprogesterone; neuroendocrine mechanisms regulating growth and reproduction in farm animals.

 

Colin Scanes

 

 

Marvin Stromer

Properties and functions of contractile and cytoskeletal proteins and filaments in skeletal, smooth, and cardiac muscle; interactions between contractile and cytoskeletal components and with their respective anchoring sites.

 

Biochemistry, Biophysics and Molecular Biology

 

Janice Buss

Signal transduction during cellular differentiation, growth and oncogenesis; molecular mechanisms by which GTP-binding proteins and tyrosine kinases interact with membranes; covalent modification of proteins with lipids.

 

Richard Robson

Investigating biochemistry, molecular biology, structure and function of specific myofibrillar and other cytoskeletal proteins of skeletal, heart and smooth muscle cells.

 

Biomedical Sciences

 

Vellareddy Anantharam

Role of Apoptosis and Cell Death in Neurodegenerative disorders.

Understanding cellular/molecular mechanisms underlying neuronal degeneration

in in vitro and in in vivo models using molecular biology tools.

 

Vlastislav Bracha

The brain mechanisms of learning, memory and goal-oriented behaviors.  This research uses combination of behavioral, neuropharmacological and neuroanatomical methods, as well as a state of the art technique of a large-scale recording of neuronal activity during learning.  

 

 

Tim Day

Mechanism of function of the neuromuscular systems of parasitic worms.

 

M. Heather West Greenlee

Development and differentiation of neural progenitors and neural stem cells derived from the retina and the brain.

 

Walter Hsu

Adrenergic receptors and neuroendocrine interactions. http://

 

Srdija Jeftinija

Research interests are mechanisms controlling the cellular signaling in glia-neuron interactions, in growth hormone secretion and in neural stem cells differentiation.

 

Anumantha Kanthasamy

Parkinson’s disease and its related movement disorders. 

 

Uhnoh Kim

GABAergic synapses role in generating major sleep rhythm and role of disruption of the system in seizures. 

 

Richard J. Martin

Physiology and pharmacology of nematode ion-channels.

 

Mirjana Randic

Chemical synaptic transmission in the mammalian spinal cord.

 

Etsuro Uemura

Interactions between neurons and glial cells are being studied in tissue culture.  Current focus is on the role of these cells in the development and regeneration of the central nervous system; Alzheimer’s disease; possible neuroimmune interactions.

 

Chemistry

 

Victor Shang-Yi Lin

Our current research interest is to develop non-invasive biocompatible nanoprobes for chemical sensing of intercellular neurochemical communications with nanoscale spatial resolution, and for control of cellular behavior at the macroscopic level.

Chemical Engineering

 

Surya Mallapragada

Developing micro and nanopatterned polymeric substrates with chemical, physical and biological guidance cues for promoting peripheral and optic nerve regeneration.

 

Computer Science

 

Vasant Honavar

Computational approaches to understanding the structure, function, behavior, adaptation, and evolution of cognitive systems (both natural and artificial with particular emphasis on memory and learning).

 

Entomology

 

Tom Baker

Development of sex pheromones, host volatiles, and other attractants for use against agricultural and urban insect pests.  Neuroethological studies of insects to understand fundamental processes of olfaction, orientation to odors, and to engineer tissue-based, hybrid olfactory biosensors.

 

Health and Human Performance

 

Ann Smiley-Oyen

How the brain controls movement, focusing on the contribution of the basal ganglia and cerebellum to the learning, planning and online control of sequential tasks, such as rapid aiming, reach to grasp and finger tapping.

Microbiology

 

Joan Cunnick

Research in the field of psychoneuroimmunology directed toward the understanding how various stressors (physical, psychological, and interoceptive) affect the immune system.

 

Psychology

 

Anne Cleary

Studies human memory with a primary research interest in episodic recognition and how it is that people come to recognize having experienced an event previously.

 

Eric Cooper

Testing and developing theories of the processes by which humans recognize visual patterns such as letters, objectives, and faces.

 

Zoology and Genetics

 

Charles Drewes

Neural correlates of rapid escape behavior in invertebrates; regeneration and plasticity of reflex pathways; neurotoxicology.

 

Jorgen Johansen

Study of the general principles underlying the assembly and function of simple nervous systems.

 

Kristen Johansen

Regulation of nuclear structure and function during cell division; developmental neurogenetics; molecular and functional characterization of neural antigens involved in axon guidance.

 

Donald Sakaguchi

Developmental neurobiology, stem cell biology, stem cell transplants as a strategy for CNS rescue and repair, development and plasticity of vertebrate visual systems.

 

Sheldon Shen

Understanding the role of intracellular ion activities during cellular activation.

 

James Bloedel

Vice Provost of Research.

 

                                                                

 Contact Information

 

Phone Number

            Toll Free: 1-866-219-9123

            Office:       1-515-294-7252

 

Address

2018 Molecular Biology Building

Iowa State University

Ames, Iowa 50011-3260

 

Email Address

idgp@iastate.edu

 

Neuroscience Program’s Website

http://www.neuroscience.iastate.edu/

 

Graduate College Website 

http://www.grad-college.iastate.edu